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Terbinafine
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Terbinafine

Terbinafine is an allylamine structurally related to naftifine. It is a synthetic antifungal agent. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine has oral and topical (cream) formulations. Oral preparation has been first introduced in 1991 in United Kingdom and approved for clinical use in 1996 in USA. It is being manufactured by Novartis Pharmaceuticals. Its trade name is Terbinafine. As with the other allylamines, Terbinafine inhibits ergosterol biosynthesis via inhibition of squalene epoxidase. This enzyme is part of the fungal sterol synthesis pathway that creates the sterols needed for the fungal cell membrane.

Other names for this medication:
Terbinafine, Lamisil,

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Terbinafine is used to treat certain types of fungal infections (e. g. , fingernail or toenail). It works by stopping the growth of fungus. This medication belongs to a class of drugs known as antifungals.

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Aspects of nature, diagnosis, mode of infection and therapy of actinomycosis are discussed. Group B Streptococcus (Streptococcus agalactiae) peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD). G-protein-coupled receptors (GPCRs) regulate a wide variety of physiological processes and are important pharmaceutical targets for drug discovery.

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This inevitably leads to problems of reproducibility and dependence upon appropriate high quality clinical material. This allows us to test site-directed mutations of acetylcholinesterase. This suggests that root arabinogalactan proteins are involved in the control of early infection of roots and highlights a novel role for these proteoglycans in root-microbe interactions.

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It has been suggested that the glycated proteins, such as Schiff base and Amadori compounds, undergo a spontaneous autoxidation reaction, catalyzed by transition metal ions, involving the O(2)(-) generation. The suggested model allows to give a noncontradictary interpretation of the hydrogen exchange data in double-helical polynucleotides. In contrast, in hepatocytes originally cultured for more than 16 h, IL-6 and dexamethasone produced a synergistic increase in MnSOD mRNA levels.

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To describe theoretical weaknesses in the DSM-IV criteria for psychotic disorders and to argue that schizophrenia-like psychosis is a neurobiological syndrome similar to aphasia or apraxia. Artificial feeding of the speckled trout, Salvelinus fontinalis (Mitchill)

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The role of short course (three doses) and single dose peroperative antibiotic (netilmicin sulfate) prophylaxis were studied in 42 patients undergoing removal of renal calculi. To observe the effect of 6-phenyl cyclic monophosphate (cAMP) on glucose uptake and cell proliferation, 2-deoxyglucose (2-DG) uptake, immunohistochemistry, Western blotting, and immunoprecipitation were carried out. Use of a low molecular weight preparation of heparin--ORG 10172 (Lomoparan) in the critically ill. The problems encountered in the immediate postoperative period in an undiagnosed myxoedematous patient are reported, the specific management of these problems discussed and the treatment of myxoedema coma outlined.

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Complex signaling cascades not only decide about cell survival, but also about the neurological deficit and the mortality after stroke. Physiologic basis and clinical application of some tests of liver function. The addition of interleukin-1 (IL-1) in combination with ExT enhanced the stimulative response of VB 2.1-bearing CTCL cells that were pre-cultured with ExT for 7 d, suggesting that IL-1 can be a co-factor for the stimulation. Data regarding palliative sedation at home in dying patients are lacking.

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Almost half of these vaccines include nonstructural HIV-1 gene products. In contrast, the oligosaccharide linked to N46 of the GP(5) protein is strongly required for virus particle production. This interpretation was supported by the results of glutamine loading. Probing the molecular interaction of chymotrypsin with organophosphorus compounds by 31P diffusion NMR in aqueous solutions. High pulse wave velocity (PWV) is related to cardiovascular risk in essential hypertension (EHT).

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An array of recent reports on the trials of active and passive immunotherapy for patients with brain tumors have documented safety and some preliminary clinical efficacy, although the ultimate judgment for clinical benefits awaits rigorous evaluation in trials of later phases. ADDITIONAL hospital dental internships and residencies approved by the Council on Dental Education. Quantitative and qualitative nature of the immune responses in bats to bacteriophage phi-X174. Establishment of a consistent and reliable quality assurance program and the production of high quality mammograms. It is, therefore, appropriate to recommend that pelvic CT scan be a routine test for every patient who has had abdominoperineal resection or low anterior resection for carcinoma of the rectum and rectosigmoid.

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Serum response factor (SRF) is a major transcription factor that regulates activity-driven gene expression in neurons. Clinically relevant concentrations of propofol may attenuate free radical-mediated and inflammatory components of myocardial reperfusion injury in patients undergoing elective coronary artery bypass graft surgery.

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The effects of an 8-week multidisciplinary programme, including 6 and 12 month follow-up, was examined with measures including health-related quality of life (HRQL), pain perception, pain stages of change and physical functioning. The expression of CD44 suppressed by CD44-specific antisense oligonucleotide was detected by RT-PCR and Western blotting.

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SqCC was the leading tumor-type in Jewish men and AC in Jewish women. cholerae (RDE) when added to the medium of eggs infected prior to deembryonation. They are intimately linked with intensity/contrast information coded by the spike density of retinal ganglion cells. Our study suggests that Sox8 and Sox10 are jointly required for the maintenance of these vagal neural crest stem cells.

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Pulmonary botryomycosis on a lung cavity: a rare pulmonary infection mimicking cancer. Hospital and clinic records of all patients with HIV infection who underwent an abdominal aortic operation were reviewed during an 11-year period.

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Chest X-ray and perfusion lung scintigraphy showed pulmonary infarction, perhaps due to vegetation-derived emboli. The optoacoustic system detects signals induced in the SSS and optoacoustic signals from the SSS linearly correlate with oxyhemoglobin saturation. Oestrogen and progesterone receptors and disease-free interval in primary breast cancer. The anti-inflammatory effect was observed in the first phase of the inflammatory process. Daily energy expenditure was calculated using these rates in conjunction with the activity diaries.

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Decreasing incidence of paroxysmal sympathetic hyperactivity syndrome in the vegetative state. Virus-like particles in chemically induced sarcomas in high- and low-leukemia strains of mice. There was also a higher correlation between serum urea and serum creatinine in Group 1 than in Group 2. Body shape ideals and perceptions of body shape in Spanish and American college students.

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Clinical use of propranolol (Sumial), and some practical and theorical findings concerning the patient under intensive care Lercanidipine enantiomers were analysed using a chiral LC-MS-MS method.

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Tumor cell proliferation was measured by MTT colorimetric assay and its apoptosis was determined by the flow cytometry (FCM). In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosine 15 (Y15) of p34cdc2, the protein kinase subunit of maturation promoting factor, accelerate the entry into mitosis and abolish the ability of unreplicated DNA to arrest cells in G2. Labeled motoneurons had a blue fluorescent cytoplasm at 360 nm excitation wavelength with FB, and a golden-yellow fluorescent nucleus with NY on the cryostat section. Fundamental aspects of radiation protection from a microbiological point of view. After summarizing the ion channels regulated by CFTR, the review focuses on the functions of CFTR that do not relate directly to a disease mechanism based on a channelopathy.

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Vascular conditioned and unconditioned reflexes in endarteritis obliterans Over half the lesions reviewed fell into the latter category and all were situated in the axial skeleton.

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Contribution of LPP copy number and sequence changes to esophageal atresia, tracheoesophageal fistula, and VACTERL association. Redox sensitive cysteine residues in calbindin D28k are structurally and functionally important. The hepatic cells at 3-4 weeks displayed the typical characteristics of immature cells: small size, a round or ovoid nucleus with dark color, scant cytoplasm with slight blue and a high ratio of nuclei/cytoplasm. Douching, pelvic inflammatory disease, and incident gonococcal and chlamydial genital infection in a cohort of high-risk women. These pathologies can be readily identified in the majority of cases by appropriate testing in the examining room, and in vestibular function or neurodiagnosic laboratories.

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The release of the National Family Health Survey results--showing the relatively wealthy state of Gujarat having deficiency levels exceeding national averages--prompted Gujarat officials to introduce fortified wheat flour in their social safety net programs (SSNPs). Uncertain biologic relevance of polymorphisms of leukotriene C4 synthase in asthma.

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Failure to inhibit in vitro or in vivo acetycholinesterase with botulinum toxin type A. Atomic absorption spectrophotometric determination of zinc in the prostate. Studies of caloric, nitrogen and electrolyte requirements in decreasing postoperative nitrogen loss. The content of n-6PUFA and n-3PUFA of the treated cells and the ratio of n-6/n-3PUFA were analyzed by chromatography. Preschool pupil performance on the Standford-Binet and the Wechsler intelligence scale for children.

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Mean arterial pressure (MAP) and its response to alpha-CGRP (1 microg/kg, iv) and its receptor antagonist, CGRP(8-37) (1 mg/kg, iv), were determined in conscious and unrestrained rats. The concentration of 5-hydroxytryptamine in human blood and its absorption by platelets.

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Skin reactivity to dinitrochlorobenzene in patients with atopic asthma Role of acetylcholinergic structures of the caudate nucleus in mechanisms of inhibition of a conditioned food-getting reflex in the cat To confirm the genetic stability of the Edmonston-Zagreb vaccine strain, we determined and compared the nucleotide sequences of genuine Edmonston-Zagreb master seed (EZ D22) and current working seed lot (EZ D24 2/99). 1970 survey of instructional television in programs for the deaf.

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Spore germination in Dictyostelium discoideum: trehalase and the requirement for protein synthesis. ABD was similar in the two groups and did not correlate with PFT and quantitative CT in either group. Study on thermo-sensitive intelligent targeting type drug carriers (I) porous membranes with grafted thermo-sensitive gates The use of standards in the administration of environmental pollution control programs. An anti-MHV3 state was observed only in A/J Mphi upon activation with IL-12/IL-18 or IFNgamma regardless of their origin from the peritoneum or bone marrow.

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Forty-four eyes of 22 consecutive patients with an established diagnosis of JHS/EDS-HT and 44 eyes of 22 age- and gender-matched control subjects. The driving force of the inhalation and exhalation processes is the filling and emptying of the alveolar volume which follows a sinusoidal pattern. enterocolitica did not interact with Salmonella, Shigella and Y. Control of acid-base equilibrium by the kidney in the toxic form of infantile diarrhea Progressive neuromuscular symptoms years after recovery from acute paralytic poliomyelitis have been termed the PPS.

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Based on the homology to other known bacterial genes, some of the RpoS-regulated genes of unknown functions are likely important in nutrient scavenging. Methodological problems in measuring gastrointestinal blood flow. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines.

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